The Sekondi Takoradi Chamber of Commerce and Industry has been in existence and has operated since 1920’s. it started and operated as a business association for the expertrates firms and businesses who came from Europe to the Gold Coast to trade in Gold, Timber and other resources that were found in abundance in the then Western Province of the Country.

Prior to 1961, there were four separate and independent Chambers of Commerce in Ghana, namely:

	The Accra & Eastern Province Chamber of Commerce;
	The Kumasi Chamber of Commerce;
	The Sekondi/Takoradi Chamber of Commerce; and
	The Ghana Chamber of Commerce

The first three Chambers of Commerce mentioned above were composed of expatriate firms and businesses based in the three main trading centres, while the fourth Chamber catered for the indigenous Ghanaian businesses.

The Ghana National Chamber of Commerce was established on November 8, 1961 under an Act of Parliament (Executive Instrument No. 196) following the amalgamation of the then existing Chambers of Commerce which were formed on racial basis. The Executive instrument was amended by Lesgislative Instrument No. 611 of 1968 to streamline some of the internal structures of the Chamber.